Drugs from the top-100 best selling drugs list that target circadian genes

February 26, 2025
 / 
civilitivilleusa
 / 
Healthcare, Big pharma and Wall Street -RC
Dataset S1: Drugs from the top-100 best-selling drugs list that target circadian genes.  
             
Rank Sales Trade name Drug Indications Circadian-gene targets Organs in which targets oscillate
1 $1.53 b Abilify aripiprazole Bipolar disorder, Major depressive disor... Htr2c, Htr1b, Htr2a, Chrm2, Drd4, Adra2b, Adra1b, Adra1a lung, heart, brainstem, white fat, adrenal gland, liver, brown fat, kidney, skeletal muscle, cerebellum
2 $1.46 b Nexium esomeprazole Gastritis, GERD, Esophagitis Atp4a liver
3 $1.30 b Cymbalta duloxetine Chronic pain, Fibromyalgia, Diabetic neu... Slc6a4 adrenal gland, kidney
4 $1.30 b Crestor rosuvastatin Hyperlipidemia Hmgcr, Abcc1, Abcc4 lung, heart, hypothalamus, liver, brown fat
5 $1.28 b Advair Diskus fluticasone + salmeterol Asthma, Chronic obstructive pulmonary di... Serpina6, Pgr, Nr3c2, Adrb2, Pla2g4a lung, heart, liver, kidney, skeletal muscle, aorta
6 $1.22 b Humira adalimumab Rheumatoid arthritis, Crohn's disease, U... Fcgr2b, Fcgr3 liver, kidney
7 $1.08 b Enbrel etanercept Rheumatoid arthritis, Psoriasis Fcgr2b, Tnfrsf1b, Fcgr3 hypothalamus, liver, kidney
10 $859 m Neulasta filgrastim Acute myeloid leukemia Csf3r lung
11 $794 m Rituxan rituximab Rheumatoid arthritis, Non-Hodgkin's lymp... Fcgr2b, Ms4a1, Fcgr3 liver, kidney, skeletal muscle
12 $726 m Spiriva tiotropium Chronic obstructive pulmonary disorder Slc22a5, Slc22a4, Chrm2 heart, brainstem, brown fat, kidney, aorta
14 $701 m Januvia sitagliptin Diabetes mellitus T2 Abcb1a, Dpp4 heart, adrenal gland, liver, kidney
16 $641 m Avastin bevacizumab Colorectal cancer, Non-small cell lung c... Fcgr2b, Vegfa, Fcgr3 heart, brown fat, liver, kidney, skeletal muscle, aorta
17 $637 m Lantus Solostar insulin glargine Diabetes mellitus T2 Igf1r kidney
18 $592 m Lantus insulin glargine Diabetes mellitus T2 Igf1r kidney
20 $538 m Diovan valsartan + hydrochlorothiazide Hypertension, Heart failure Slc22a6, Agtr1a, Slco1b2, Car4, Kcnma1, Car12, Car2 heart, adrenal gland, liver, kidney, skeletal muscle
22 $518 m Celebrex celecoxib Osteoarthritis, Rheumatoid arthritis Ptgs2, Pdpk1, Abcc4 lung, brainstem, brown fat, aorta, cerebellum
24 $471 m Herceptin trastuzumab Breast cancer Fcgr2b, Erbb2, Egfr, Fcgr3 heart, liver, kidney
26 $438 m Gleevec imatinib Chronic myeloid leukemia Ptgs1, Kit, Slc22a2, Abcg2, Pdgfra, Pdgfrb, Ddr1, Abca3, Abl1, Ret, Abcb1a lung, heart, brainstem, white fat, adrenal gland, brown fat, liver, kidney
27 $431 m Vyvanse lisdexamfetamine Attention deficit hyperactivity disorder Adra1b liver
29 $415 m Lucentis ranibizumab Macular degeneration Vegfa heart, brown fat, liver, skeletal muscle, aorta
30 $413 m Synagis palivizumab Respiratory syncytial virus Fcgr2b, Fcgr3 liver, kidney
31 $395 m Zetia ezetimibe Hyperlipidemia Soat1, Abcc2, Anpep, Abcb1a lung, heart, brainstem, adrenal gland, liver, kidney
32 $392 m Tamiflu oseltamivir Influenza Neu2, Neu1, Ces1g, Slc22a8, Slc15a1, Abcc4 lung, liver, brown fat, kidney, cerebellum
33 $383 m Ritalin methylphenidate Attention deficit hyperactivity disorder Slc6a4 adrenal gland, kidney
34 $377 m Symbicort budesonide + formoterol Asthma, Chronic obstructive pulmonary di... Adrb2 lung, kidney, skeletal muscle
36 $365 m Lovenox enoxaparin Deep vein thrombosis, Myocardial infarct... Serpinc1 liver
37 $348 m AndroGel testosterone Hypogonadism Slc22a4, Slc22a3, Ar, Cyp1a1, Cyp2b10, Akr1d1, Abcg2, Cyp1b1, Cyp17a1, Cyp2a5, Slc22a8, Abcb1a, Maoa lung, heart, brainstem, white fat, adrenal gland, liver, brown fat, kidney, aorta, cerebellum
38 $346 m Lidoderm lidocaine Pain Slc22a5, Cyp2b10, Egfr, Abcb1a lung, heart, adrenal gland, brown fat, liver, kidney, aorta
39 $338 m Avonex interferon beta-1a Multiple sclerosis Ifnar2 skeletal muscle
41 $332 m Rebif interferon beta-1a Multiple sclerosis Ifnar2 skeletal muscle
44 $304 m Seroquel XR quetiapine Bipolar disorder, Major depressive disor... Htr2c, Htr1b, Htr2a, Chrm2, Drd4, Adra1d, Adra2b, Abcb1a, Adra1b, Adra1a lung, heart, brainstem, white fat, adrenal gland, brown fat, liver, kidney, skeletal muscle, cerebellum
45 $289 m Viagra sildenafil Erectile dysfunction Cyp1a1, Pde6g, Abcc5, Abcc10, Pde5a, Cyp2e1, Abcc4 lung, heart, brainstem, white fat, adrenal gland, hypothalamus, brown fat, kidney, aorta, cerebellum
47 $281 m Niaspan niacin Hyperlipidemia Slco2b1, Slc22a5, Qprt, Slc16a1 lung, heart, brainstem, adrenal gland, white fat, hypothalamus, liver, brown fat, kidney, aorta, cerebellum
48 $279 m Humalog insulin lispro Diabetes mellitus T2 Igf1r kidney
49 $274 m Alimta pemetrexed Mesothelioma, Non-small cell lung cancer Tyms, Atic, Gart, Slc29a1 lung, heart, brainstem, brown fat, liver, kidney, aorta
51 $268 m Tricor fenofibrate Hyperlipidemia Ppara lung, heart, white fat, adrenal gland, brown fat, liver, kidney
54 $267 m Combivent ipratropium bromide + salbutamol Asthma, Chronic obstructive pulmonary di... Slc22a5, Slc22a4, Chrm2, Adrb1, Adrb2 lung, heart, brainstem, brown fat, kidney, skeletal muscle, aorta
56 $262 m ProAir HFA salbutamol Asthma, Chronic obstructive pulmonary di... Adrb1, Adrb2 lung, kidney, skeletal muscle
57 $253 m Cialis tadalafil Erectile dysfunction Pde5a adrenal gland
62 $240 m Janumet metformin + sitagliptin Diabetes mellitus T2 Slc47a1, Slc22a2, Prkab1, Abcb1a, Dpp4 heart, brainstem, adrenal gland, hypothalamus, liver, brown fat, kidney
63 $240 m Neupogen filgrastim Acute myeloid leukemia Csf3r lung
66 $236 m Toprol XL metoprolol Hypertension, Heart failure Slc22a2, Adrb1, Adrb2, Abcb1a lung, heart, adrenal gland, brown fat, liver, kidney, skeletal muscle
70 $220 m VESIcare solifenacin Overactive bladder Chrm2 heart, brainstem
71 $220 m Vytorin ezetimibe + simvastatin Hyperlipidemia Hmgcr, Cyp2b10, Soat1, Abcc2, Anpep, Abcb1a lung, heart, brainstem, adrenal gland, brown fat, liver, kidney, aorta
73 $219 m Provigil modafinil Narcolepsy, Shiftwork sleep disorder Cyp2b10, Adra1b lung, brown fat, liver, aorta
78 $209 m Aciphex rabeprazole Gastritis, GERD, Esophagitis Cyp1a1, Atp4a, Abcg2 lung, heart, brainstem, white fat, liver, brown fat, kidney
83 $201 m Synthroid levothyroxine Hypothyroidism Slc16a2, Serpina7, Thrb, Thra, Abcb1a lung, heart, white fat, adrenal gland, brown fat, liver, kidney, aorta, skeletal muscle, cerebellum
84 $198 m Evista raloxifene Osteoporosis Ncoa2, Cyp2b10, Esr1, Esr2 lung, white fat, brown fat, liver, kidney, aorta
87 $196 m Betaseron interferon beta-1b Multiple sclerosis Ifnar2 skeletal muscle
88 $193 m Lipitor atorvastatin Hyperlipidemia Hmgcr, Cyp2b10, Ahr, Abcc5, Abcc1, Abcb1a, Abcc4, Dpp4 lung, heart, brainstem, white fat, adrenal gland, hypothalamus, brown fat, liver, kidney, aorta, cerebellum
90 $189 m Lunesta eszopiclone Insomnia Ptgs1, Tspo, Gabra3 lung, heart, adrenal gland, kidney
97 $175 m Xeloda capecitabine Breast cancer, colorectal cancer Cda, Tymp, Tyms, Ces1g, Dpyd lung, adrenal gland, liver, brown fat, kidney, aorta
98 $173 m Prilosec omeprazole Gastritis, GERD, Esophagitis Cyp1a1, Atp4a, Abcg2, Cyp1b1, Abcb1a lung, heart, brainstem, white fat, adrenal gland, brown fat, liver, kidney
99 $171 m Focalin XR dexmethylphenidate Attention deficit hyperactivity disorder Slc6a4 adrenal gland, kidney
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